To ensure effective management and monitoring of Genome Canada funded projects and science and technology platforms, Genome Centres have been established in each region across Canada. These Centres facilitate access to leading edge technology for researchers, allow for different approaches to project development and fundraising, and provide opportunities for public outreach programs at a regional level.

Each Centre is established as a not-for-profit organization. A contractual agreement with Genome Canada outlines specific terms and conditions for the funding of large-scale research projects and science and technology platforms in genomics and proteomics.