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GenomicsPowerPromisethethePOST-CONFERENCEMAGAZINEEXTENDEDDIGITALEDITIONDECEMBER2014 CONCORDIA.CACENTREFORAPPLIEDSYNTHETICBIOLOGYBEPARTOFTHETHINKINGMAKINGMEDICINEFORTHEMASSES 1llaspectsoourhealthandwellbeingdependonahealthyenvironment.InCanadawehavearesponsibilitytoprotectourreshwaterreservesabundantorestsandexpansiveagriculturallands.Andweneedtolearntoextractoursignifcantmineralandossiluelsresourcesinanenvironmentallysustainablemanner.Asmanyothesechallengesweacearecontrolleddirectlyorindirectlybybiologicalsystemsourunderstandingohowthesesystemsworkwillhelpusfndsolutions.AlllieormsthatcontributetothesesystemsareinturncontrolledbygenomesmadeoutoDNAthebuildingblocksolie.Genomics-whichdealswiththeanalysisandunctioningoentireDNAsequencesinhumanandotherorganisms-willbeakeyenablingtechnologyweneedtomasterinordertoharnessthepowerobiologytohelpusremediatemanyothesiteswhoseecologywevecompromised.CanadaisrecognizedasaworldleaderingenomicsthankstosustainedederalinvestmentsthroughGenomeCanadamorethan1billionsince2000matchedbycoinvestmentsingenomicsprogramsandprojectsbyprovincialgovernmentstheprivatesectornonproftsandinternationalpartners.WehavedevelopedormidableresearchcapacityinthisrelativelyyoungscienceandareattheleadingedgeotranslatinggenomicsapplicationsacrossarangeosectorsoimportancetoCanadianshealthagricultureorestryfsheriesandaquacultureandincreasinglyenvironmentalprotectionandsustainableresourcedevelopmentintheenergyandminingsectors.FromtheConferenceCo-ChairsAHealthEnvironmentRenewablesResourcesWhatdoesgenomicsmeanfortheenvironmentEverything.BecauseCanadastandstogainconsiderablyromintegratinggenomicsintouseinsocietyacrosssectorsandbecausemanyintheworldarelookingtousasleadersinthisfeldtherewillbegreatinterestinamajorinternationalconerenceCanadaishosting.ItscalledGenomicsTePowerandthePromise.Teconerenceisocusedongenomicswithapplicationstotheenvironmenthealthandothersectorsandisauniqueassembly.Tereareocourseleadingpractitionersandthinkersinscience.Butthisgatheringismoreitsaboutinvitingothersintoseethepotentialogenomicsandtoseekguidanceonitsbenefcialuses.Sotherewillalsobepolicymakerswhograpplewithsocietyschallengesbusinesspeoplewhogrowtheeconomyacademicswhoconsidertheissuescriticallyandthoseromnonproftswhoseektoensurebeneftsaresharedequitably.Weneedabroaddiscussionbecausethescienceogenomicshassuchawiderangeoapplications.Perspectives 2ForexampleCanadianresearcherPaulHebertwholeadstheInternationalBarcodeoLieProjectthelargestresearchprogrameverundertakeninbiodiversitysciencewilltalkaboutprogressincreatingabio-literateworldwhereeveryspeciescanbeidentifedinminutes.Tisishelpingenvironmentalstewardsknowwhetheraspecimenisindigenousoraninvaderatriskorinabundance.IsafshflletonsaleinyourlocalmarketromanendangeredspeciesorahealthypopulationandiseventhekindofshitpurportstobeonthelabelGeneticmaterialtellsthewholetalearminguswithaccurateinormationandatoolorpolicy-makerstodeterminethebestcourseoactionoroursociety.CanadianresearchersarealsoworkingongenomicssolutionsorenvironmentalandotherchallengesinCanadasnon-renewableresourcesectors.Teyareidentiyingmicrobialliethatremediatespollutedsitesacceleratingthetransormationoindustrialsitestoanaturalstatemuchmorequicklyandsaely.Othersareexploringtheroleogenomicsinsaeguardingourorestsandenhancinghealthcaretheenvironmentsimpactonhumanhealthandstrategiesoradaptingtoclimatechange.TereareewcountrieswithasmuchtogainromgenomescienceasCanadabecausewehaveoneothelargestrichestandmostpristineenvironmentsontheplanet.Ourprosperityislinkedtothehealthoourpopulationtoresourcedevelopmenttoagriculturetocoastalindustries.Understandingthenatureoallliethroughgenomicswillmakeusbetterstewardsothatenvironmentandbringoursocietyandeconomyingreaterbalancewiththosenaturalsystems.PierreMeulienJohnH.DirksPresidentCEOGenomeCanadaPresidentScientifcDirectorGairdnerFoundationGenomicsThePowerandthePromisetookplaceromNovember24-262014inOttawaCanada.TisinternationalconerencewashostedbyGenomeCanadainpartnershipwithTeGairdnerFoundation.TeeventexaminedthethemeGenomicsandtheEnvironmentthroughaseriesopresentationsandpaneldiscussionsinvolvingworld-renowngenomicsexpertsandvisionaries.Wearepleasedtobringyousomeotheconerencehighlightsthroughthisspecialmagazine.Alsoseehowtheconversationunoldedonwitterviahashtagpowerogenomics.Fulldetailsabouttheconerenceprogramandspeakerscanbeoundatpowerandpromise.cvent.com2014.TisarticlefrstappearedasanopinionpieceintheGlobeandMailonlineonNovember262014Formoreinormationabouttheconerenceco-chairsvisitwww.genomecanada.cawww.gairdner.org 3r.EricGreensayssomeotheearliestwinsinclinicalgenomicswillbeincancer.WhenEricGreenstudiedmedicineinthe1980sthewordgenomicswasjustcreepingintostudentsvocabularyandtheHumanGenomeProjectwasstilljustinplanning.Itsbeenthreedecadessincetheeldogenomicsemergedandnowtheworldsaverydierentplace.GreenisembarkingonhisfhyearasdirectorotheNationalHumanGenomeResearchInstituteandsayshesollowingintheootstepsorockstarsosciencewhohavesequencedthehumangenomeandheplanstoturna1billioninternationalprojectintoapracticaltoolintheghtagainstcancer.GreenscareercanlargelybetrackedthroughtheInstituteanentitywithintheNationalInstitutesoHealthintheU.S.wherehesworkedorover20years.Hestartedasajuniorinvestigatorworkingonthehumangenomeprojectandthenheassumedvariousleadershippositionsuntilnallybecomingdirector.ItsprettyhumblingwhenyouollowintheootstepsogiantssaidGreenoNobellaureateJamesWatsonandFrancisCollinstheonlypreviousdirectorsotheNationalHumanGenomeResearchInstitute.Tehumangenomeprojectended11yearsagobuteversincetheresbeenanescalationintechnologyandinormationabouthowthehumangenomeworksitsroleinhealthanddiseaseandwaystousegenomicinormationormedicalcare.AferGreenandhiscolleaguessequencedthe1-billiongenometheinstitutelaunchedaprogramtodeveloptechnologiesthatscalethecostbackathousandtimeover.Sohavinghadabillion-dollargenomenowwewantedtocreate1000genomeGreensaid.Andremarkablyyouast-orwardtotodayandwerewithinstrikingdistanceohavinga1000genome.IthinkitsoneothegreatesttriumphsinbiomedicalresearchoverthelastdecadeitsveryexcitingsaidGreen.DItschangingthefaceofcancerdiagnosticsandprognosisandIthinksomeoftheearliestwinsinclinicalgenomicswillbeincancer.GenomicMedicinePhotobyJean-MarcCarisse2014EricGreen 4Intermsoapplicationsousinggenomicinormationaspartoclinicalcaretherearethreeprimaryareasornow.Numberoneisgoingtobecancer.Nowwehavemethodsthatallowustoreadacancersgenomewhichgivesusinormationinmuchmoredetailaboutwhatswronginthegenomeothatparticulartumour.SequencingatumoursgenomegivesarmoreinormationthanwhatwecangleanromlookingunderamicroscopeorbyconductingtestsGreenexplained.ItschangingtheaceocancerdiagnosticsandprognosisandIthinksomeotheearliestwinsinclinicalgenomicswillbeincancer.Secondareaoapplicationalreadyhereandnowisorultra-raregeneticdiseases.Greensaidtherearemanystoriesopatientswithillnessesthathaveeludeddiagnosisbecausephysicianscantgureoutwhatswrongwiththepatientbutnowpatientscanhavetheirgenomessequenced.Betweenaquarterandthirdothetimeinsuchcasesyougureoutwhatswrongwiththatpatientsimplybylookingattheirgenomicsequence.Greensaidthatthisisbeingdoneroutinelyhundredsotimesamontharoundtheworld.IntheU.S.genomicsequencingisdoneallthetimeordiagnosticsincaseswherephysicianscannotgureoutwhatswrongwithapatient.Tethirdareaworthmentioningwhichisalsohereandnowispharmacogenomics.Pharmacogenomicsstudieshowthedierencesinourgenomeswillmakeusrespondwellorpoorlytoagivenmedication.KnowingsomethingaboutsomebodysgenomehelpsdecidethebestmedicinetogivethemandtherightdoseexplainedGreen.ForsomedrugsincludingoneothemaindrugsortreatingAIDSitsofenconsideredimportanttorstgetgenomicinormationaboutaspecicgenevarianttodeterminewhetherthatsagoodmedicationorthatpatientornot.Butlikeanynewdevelopmentinmedicinesequencinggenomescomeswithitsownarrayoethicalconcerns.ForinstanceGreensuggestedthatanindividualwhoisintheir20smayormaynotwanttoknowitheywillhaveearlyonsetdementia.Anotherareaocontentionisdeterminingwhoshouldbeallowedaccesstoanewbornsgenomicinormation.FortdevingtansdexprienceenrechercheengnomiqueleDrEricGreenestheureuxdetravaillerdanslesecteurleplusexaltantdelarecherchescientique.DirecteurdepuiscinqansduNationalHumanResearchInstituteauxtats-Unisilestparticulirementerdavoircollaborlamiseaupointdestechnologiesquiontpermisderduirelecotdusquenagedegnome.Ralisaucotdunmilliarddedollarsilyaonzeanslesquenagegnomiquecoteaujourdhuiquelque1000.LInstitutderecherchequildirigeseconcentresurlexploitationdesdonnesgnomiquesdanstroisdomaineslecancerlesmaladiesgntiquestrsraresetlesapprochespharmacognomiques.EnBrEf 5WhatdowedowithnewbornsIwesequencetheirgenomeswhichwedowhoshouldhaveaccesstothatinormationWeanticipatedethicalissuesevenbeorethegenomeprojectbeganwhichiswhyourinstitutestartedtheEthicalLegalandSocialImplicationsResearchprogramELSI.WhilemanyaspectsosequencinggenomesisdauntingGreensaidhecantimagineworkinginanyothereld.Itsexhilaratingbecausethescienceissoexciting.ImeangenomicsIjustcantimagineabetterplacetobeworkingscienticallythangenomicsespeciallyasaphysician-scientistitsjustsoexciting.Greencomesromaamilyoscientistshisatherisavirologistnowinhislate80sandstillanactivescientisthisbrotherisaprominentmolecularbiologistandhissisterisapediatrician.TepedigreeseemslikelytocarryoninGreenschildren.Heandhiswiewhoisaphysicianhaveasonstudyingbiologyinuniversityandadaughterstillinherteenswhoisgoodateverythingandhintsatbecomingaphysician.GreensaidhejumpedattheopportunitytoparticipateintheGenomicsTePowerTePromiseconerencebecausehesalwayshappytoworkwithcolleaguesinCanada.OurinstituteandgenomicresearchintheUnitedStateshasalwayshadaveryproductiveandenjoyablerelationshipwithGenomeCanada.Wevealwayshadreallygoodrelationshipsandregardedthemasgoodriendsandcolleagues.-JaniceDicksonEthicalimplicationsEDITORJamesBaxterDEPUTYEDITORSDougBeazleyIanSheltonLisaVanDusenREPORTERSJaniceDicksonKelseyJohnsonJamesMunsonAliceMusabendeElizabethTompsonYaminasalamlalBJSiekierskiKirstenSmithResearcherKristieSmithPHOTOGRAPHERJean-MarcCarisseGRAPHICDESIGNERSarahWestBUSINESSTEAMJohnButtereldCOOSallyDouglasDeputyPublisherCallieSandersonEmilyFrancisCONTACT201-17YorkStreetOttawaOntarioCanadaK1N9J6Ofce613-789-2772iPoliticsisyourdigitalsourceorindependentup-to-the-minutecoverageoCanadianpoliticsandthebusinessogovernment.Learnmoreatipolitics.caGenomicsTePowerTePromiseConerenceMagazinecreatedbyiPoliticsundercontractwithGenomeCanada. 6Neurogenomicsraindiseasesaremorecommoninthechildrenoolderathers.Tisseeminglysimplecorrelationishelpingdriveresearchthatmightbringthepromiseogenomicsresearchoutothelabandintoclinicalpractice.GuyRouleauotheMontrealNeurologicalInstituteandHospitaldiscussedthatactinlightohisteamsresearchocussedonthreediseasesSchizophreniaAutismandIntellectualDeciency.RouleauwasjoinedbyEricGreenandYvonneBombardatthisyearsTePowerTePromiseconerencetodiscusshowthehumangenomeprojectsdividendsarebeingappliedtogeneticmedicine.Rouleausaidthatmostbraindiseaseshaveagenomicbasisbutpresentapracticalhurdletostudy.Unlikeotherorgansitsdifculttoacquirebraintissuetostudy.Bydenitiononceyougetsomebodysbrainthebrainhadtobedeadbeoreyougotitopposedtothehearthesaid.RouleaushypothesisisthatthediseasesSchizophreniaAutismandIntellectualDeciencyaretheresultomultiplevariantsinanyhundredsogenes.Howeverindividualswiththesediseaseshavereducedreproductiontheyrenothavingchildrenheexplained.Rouleausaidalongsideresearcherstheylookedat402genesandound15denovomutationswhichisamutationthatoccursinaneggorspermcellorthoseaerertilization.HesaidtheyoundstrongevidencethatsuchmutationscauseSchizophreniaandAutism.TeywerebadmutationsSchizophreniaandAutismdiseaseBBringingthepromisetothepatientTheriskofhavingachildaffectedwithoneofthesediseasesincreasedwithpaternalage.PhotobyJean-MarcCarisse2014GuyRouleau 7arecausedbydenovomutations.Itpannedoutorallthreediseases.Rouleausaidthestudyexposedthattheathersgeneswhichtheysequencedshowedacompletelackoproteinproductionandthatmanyothegenessequencedwereinvolvedinallthreediseases.Werendingthatinactthereseemstobesomethingincommonbetweenthesethreediseasesatleastgeneticallyspeaking.TeriskohavingachildaectedwithoneothesediseasesincreasedwithpaternalageRouleauconcluded.Dr.EricGreendirectorotheNationalHumanGenomeResearchInstitutesaidthatcommondiseasessuchasAlzheimersanotherbraindiseaseareafictingpatientswhoarellinghospitalstoday.Commondiseasespresentachallengetoresearchersbecausethereisarangeovariantsandriskstothosevariants.Tenexttenyearswillbringustremendousinsighttodeterminingtherisksoalldiseasesinthatcategory.Greenemphasizedthatresearchersaregettingclosertousinggenomicsinclinicalcarebuttheresstillalongroadahead.ItsgoingtobeanextremelylongjourneyandIwouldcontendwearewelldowntheroadothatjourneybutwehavetorecognizehowtrulydicultthatwillbehesaid.Dr.YvonneBombardaresearcherwithSt.MichaelsLiKaShingKnowledgeInstitutesharedhercolleaguesexcitementinthepromisegenomicsoersinadvancinggeneticmedicine.ButdespitetheactthatscientistsandresearchersaredevelopingtechnologiestoenablegenomicstodiagnoseandtreatpatientsBombardsaidthereareservicecapacityissuesandarangeoethicalissues.BombardsaidCanadianhealthcareandregulatoryinrastructurehasntkeptupwithgenomicmedicine.Laplupartdespathologiesducerveauontunondementgnomiquemaisilestquasiimpossibledeltudierparcequelestissuscrbrauxontpartiedesorganesducorpshumainlesplusdicilesdaccs.lalumiredelarechercheeectueparsonquipeleDrGuyRouleaudelInstitutethpitalneurologiquesdeMontralaexpliquavoirlapreuvequelesmaladiestellesquelaschizophrnielautismeetladcienceintellectuellequirsultentdesmultiplesvariantesdescentainesdegnessontcausesparunesortedemauvaisemutationgntique.PourDrGreenlanalysedesmaladiescommelAlzheimerreprsenteunddetailleparcequelesvariantesetlesrisquesconnexessontnombreux.DreBombardrappellequelapromessedelagnomiquelamdecinegntiquedoitallerdepairaveclesconsidrationsthiques.EnBrEfResearchersaregettingclosertousinggenomicsinclinicalcarebuttheresstillalongroadahead 8Wehearofsixto12monthwaitingliststoseeageneticcounsellorandtherearefewerinourruralareasshesaidthisissuewillincreasewhengenomicsequencingbecomesmainstream.WhiletherearealotofadministrativeissuestobeconsideredBombardsaidethicalissuesliewithintheresultsofgenomicsequencing.Intheprocessofdecodingapersonsgenomeoratumourinthecancerdomainwearegoingtobeinevitablyrevealingawholeslewofpatientspredispositionstootherdiseasescancerstheirriskstocommondiseasescardiovascularwemayalsobeuncoveringcurrentundiagnoseddiseases.Bombardcomparedthelargescopeofresultsthatwouldpotentiallyberevealedtoatsunamiofinformation.Patientswhohavetheirgenomessequencedrequireintensivecounsellingabouttheirresults.-JaniceDicksonAPPhotoDavidGoldmanYvonneBombardPhotobyJean-MarcCarisse2014 9PersonalGenomehatbeganasanewanddauntingareainsciencehasbecomeanavenueosel-empowermentatleastorBradPopovichGenomeB.C.schiescienticofcer.PopovichtoldacaptivatedaudienceabouthispersonalexperiencewithunderstandinghisowngenomeattheGenomicsTePowerTePromiseconerenceinOttawa.SomehowIendedupopeningupmyrontdoorandseeingmyselonthecoverothenewspaper.IguessitwasaslownewsweekwithastoryomypersonalgenomebeingtheresaidPopovich.Elevenyearsagothersthumangenomewassequencedwithapricetagoroughly1billiondollars.TisinormationenabledscientiststodeterminethesequenceonucleotidebasepairsunveilingthehumanDNAcode.Tephysicalexpressionogeneswithinthehumangenomecouldthenbeidentiedgivingscientistsandresearchersanideaohowtheyunction.Popovichspenthiscareerrunningclinicallaboratorieswhereheexaminedgenomesbutwhentheopportunitycametolookathisowngenomeheconsultedhiswie.TeresultsohisgenomicsequencecouldshowarangeodiseaseshecouldbepredisposedtoromAlzheimerstovariousormsocancer.ButwithhiswiesencouragementsheaskedWhywouldntyouTisiswhatyoudo.hewentaheadandbegantheprocess.WBradPopovichImholdingmygenomeinmyhandhereliterallyPhotobyJean-MarcCarisse2014BradPopovich 10TerststepwasselectingaprogramtoparticipateinandhechoseIlluminabasedinSanDiegobecauseitsprogramrequirespatientstomeetwithphysiciansrequiresphysicianapprovalandthephysicianhastoorderthetest.Butintheendyoualsogetbacktheresults.Tatswhatsmostimportant.Itspersonalempowermentthatskeyhesaid.InNovember2013ImetwithmyphysicianIgavemyconsentandIhadtheblooddrawn.InearlyFebruary2014theclinicalreportcamebackandinMarchIattendedaone-daycourseonunderstandingyourgenome.Hesaidhelearnedwhathecallshisvitalorvariantstatistics.Popovichsgenomeshowedoverthreemillionvariantsandinover19000areasandhedescribedhavingmanybadgenes.YethereIam60-years-oldwalkingtalkingtoyouanddoingjustne.SoormepersonallythiswasaverygoodexperiencehesaidmotioningtohisiPadontheprojectorscreen.WhatImdoingisImholdingmygenomeinmyhandhereliterallyrighthereonaniPad.Popovichsaidhecanpickadiseaseandhisgenomecouldshowourdiferentgenesthatrelatetothatdisease.Ocourseapatienthavingknowledgeotheirgenomechangestherelationshiptheyhavewiththeirdoctor.MyphysicianandIhaveclearlybecomemoreocusedonareasomygenomethataresignicanttomyuturehealth.Hesaidtherewasavoilmomentwhereheandhisdoctordecidedtopaycareulattentiontooneareaohishealththatwasdeemedactionableasaresultohisgenome.Itwas5000todothisanditwaswortheverypennyhesaid.AlexDickinsonseniorvicepresidentostrategicinitiativesatIlluminasaidthatwithasteeppricetaghavingyourgenomesequencedisntaservicemeantorthegeneralpublic.Itsnotabroad-basedprogramitsaimedatpeoplewhoareinteresteddecisionmakersdoctorsorgeneticproessionalssaidDickinson.Nottomentiontheactthatasthenumberoindividualswhohavetheirgenomessequencedincreasessodoestheneedtounderstandthesocialethicalandlegalissuesaroundsharingthatdata.DickinsonsaidissuesaroundprovidingapatientsgenomicLadcouvertedusquenagedugnomehumainilya11ansamarquledbutdunerenouvelleetofertdespossibilitsinditespourlasciencehumaine.PouvoirtudierlesdimensionsdelADNhumainaouvertlaportelacomprhensiondesprdispositionsgntiquescertainesmaladies.UneinnovationqueBradPopovichdirigeantscientiqueprincipaldeGnomeBCachoisidevivredeaonpersonnelleetdelaquelleilestsortiortduneconnaissancedesoiplusapproondie.DepuisquilsestaitexamineretadcouvertsongnomepersonnelM.Popovichetsonmdecinsaventprivilgierlesaspectslesplusimportantspoursasant.Lesautrespanelistesontaborddesquestionsrelativesaucotetauxenjeuxthiquesetsociauxassocisaudpistagegntique.EnBrEf 11inormationpubliclyororourhealthcareandregulatorypurposesiscomplicatedandraisesagreatdealolegalcomplexities.ButPopovichisauniquecasebecauseohisbackgroundandunderstandingomoleculargeneticsandhesaidhessharedhisgenomicdatawithtwopublicsources.IpeoplewanttointerrogatemygenomeandcomebackandaskmeaquestionImhappytoansweritbutweneedaninrastructuretodothat.IncontrasttoPopovichswillingnesstoprovidehisgenomicdatamanyCanadianswouldbewaryotheactthatCanadaistheonlyG8nationthatdoesnothavepoliciestopreventgeneticdiscrimination.Tismeansthatanemployerorinsurancecompanycouldrequestapersonsgeneticrecordbeorehiringorapprovingthepersonorinsuranceandcouldmakeadecisionaboutthatpersonbasedontheirgeneticinormation.ProessorandscientistYvonneBombardsaidtherearemanyethicalandsocialissuesinvolvedwithgeneticsequencingandthatgeneticdiscriminationhasgarneredalotoattention.Bombardsaidgeneticdiscriminationexistsintheemploymentsectorandalsoininsuranceapplications.Whiletheutureandpromiseopersonalizedmedicineandgenomictechnologyiscompellingandexhilaratingandpersonalizedmedicineiscertainlynowandpresentourhealthcareandregulatoryinrastructurehasnotkeptupthepace.ButBombardsaidapromisingbillhasbeenthroughtworeadingsattheSenateiscurrentlyundergoingpublichearingsatthesenatecommitteeorhumanrightsandshewillbeverysurprisediitdoesntpass.ransparencyisexactlywhatweneedorthepublictoalsoquellsignifcantconcernsaboutundergoinggenetictestingbecauseinactthatisthereasonthereisamajorbarriertoaccessingtestsisthisideathattheirtestresultsmaybeusedagainstthem.PopovichsaidCanadiansneedtohaveacan-doattitudeandthatweneedtomoveorwardwithgenomicsequencingbecausetherestotheworldis.Asthenumberofindividualswhohavetheirgenomessequencedincreasessodoestheneedtounderstandthesocialethicalandlegalissues-JaniceDickson 12GenomicsPowerPromisethetheHenryFriesenwithpostLauraBradenJayIngramSallyAitkenMinisterofStateScienceandTechnologytheHon.EdHolderSenatorKelvinOgilvieSharonMoalemdeliverskeynotepresentationSharonMoalemJohnDirks 13rprizewinnerJayIngramEmceeDavidBaileyCEOGenomeAlbertaPierreMeulienGenomeCanadaPresidentCEOJohnDirksGairdnerFoundationHenryFriesenwithposterprizewinnerAlbertUgochukwuPosterprizewinnerDianaGranadoswithHenryFriesenGenomeCanadaChairLorneHepworthleftwelcomesguestsatreceptionAllImagesJean-MarcCarisse2014JuliaFoght 14EnvironmenthemicrobiomewasofciallydiscoveredaroundthesametimeasthemicroscopesaidproessorGeorgeWeinstockbutitspotentialasarontierohumanhealthislesswellknown.WeinstockotheJacksonLaboratoryorGenomicMedicinewasspeakingaboutanenvironmentbutoneinternaltohumanbodies.Microbiomesreertoallothemicroorganismsthatarecolonizingyourbodysuchasvirusesbacteriaandungi.Terearecommunitiesomicro-organismsandthehumanbodyisanenvironmentandmicrobesarethebiologicalcomponentothatenvironmenthesaid.Iyoudidaheadcountocellsinyourbodyyouwouldseethatyouhave10timesmoremicrobialcellsthanhumancells.Hesaidmostmicrobesareconcentratedinthegutbuttheyareeverywhereinthehumanbody.Microbescontributeatremendousamounttogeneticcapabilitytheyhelpusdegradethingsthatwedonthaveenzymesorinourowngenome.Hesaidmicrobescanadapttoanyenvironmentandtheyextractenergyandlearntosurviveinthoseenvironments.Giventhatrangeoactivitieshavingthosemicrobesandtheirgeneticcapabilityinyourbodygivesyoualotogeneticcapability.WithmostCanadiansmorelikelytoidentiymicrobesasthreatsthanalliesitmaycomeasasurprisetomanythatthecommunityomicrobesinourgutmightbekeytooursuccessontheplanet.TedevelopmentoacquiredimmunityandthekindosophisticateddeencemechanismsthatwehavearereallywaysoourbodytalkingtoourmicrobiomeandallowingustotoleratesuchaTKnowwhatsinyourgutsSequencingandtreatingthemicrobiomeGeorgeWeinstockPhotobyJean-MarcCarisse2014 15richcollectionoorganismsandthereorebenetromarichercollectionomicrobialgenesandgeneticcapabilitiesthanotherorganismsWeinstocksaid.Tescienticbreakthroughinsequencingheaddedenabledresearcherstolookatcomplexmixturesoorganismsandsamplethem.Oncethathappenedthedoorswereopenorthewholeeldomicrobiomeresearch.Inmetagenomicanalysisyouwouldsequenceasampleandseeallotheorganismsthatarepresentandyoulookorthepathogenhesaid.Weinstocksaidtheirmostcommonsamplestudiedisthestoolsampleremindingtheaudiencethatmostbacteriaisinyourgut.Lookingatastoolsampleisanon-invasivewayounderstandingbacteriainsomeonesguthesaid.Aer200sampleswerestudiedtheresearchersdeterminedthatdierentdominantorganismsappearedineachsample.Heresmicrobiomeanalysisinactionheresasuccess.Wecantakeabunchoindividualswecantaketheirpoowecansequenceitbuildourtablesandcomparethemlowandbeholdtheyallintodierentclasses.TeposterchildormicrobiomesuccessrightnowisecaltransplantingthisisthetherapyusedtotreatC.difcilediarrhoeaandinectionswherethegutmicrobiomehasbeentakenoverbyharmulbacteria.HesaidiyoutakeamicrobiomeromahealthypersonsgutandtransplantitthosebugstakeoverromC.difcileandtheproblemgoesaway.WhileWeinstockocussedonourinternalenvironmentDr.AndrewFeinbergcastshisattentiononthemicroenvironmentthatimpactshumanhealth.FeinbergotheCenterorEpigeneticsatJohnHopkinsUniversitysaidthattherearediseasesweknowareaectedbytheenvironment.Tingslikesmokingcausesdiseasethesuncausesdiseasegettingoldcausesdiseasethatdoublewhoppercheeseburgertheseareallcausesodisease.FeinbergsaidthemostlethalcancerintheworldisHepatocellularcancerwhichiscommoninAsiabutnotoenstudiedinNorthAmerica.Ladcouvertedumicrobiomehumainsestaiteenmmetempspresquequecelledumicroscopemaissonpotentielpourlasanthumaineestencoremalconnu.GeorgeWeinstockduJacksonLaboratoryorGenomicMedecineexpliquequelesmicrobescescommunautsdemicroorganismesvivantdanslecorpshumaincontribuentnormmentlacapacitgntiqueducorpshumain.LesquenagedugnomepermetaujourdhuidanalyserlemlangecomplexedecesorganismesetdeprogresserversuntraitementdesinectionsintestinalestellesqueCDifcileouladiarrhe.DrFeinbergduCenterorEpigeneticslUniversitJohnHopkinsabordelemicrobiomeduneautreaonenanalysantpluttcommentleschangementsdanslenvironnementontuneetcausalsurlesmaladiestellesquelecancer.EnBrEf 16ItiscausedbyvirusesandcarcinogensandwhatpeoplegetiscirrhosiswhichbydefnitionisinjuryandrepairwhichisapurelycausalactorinthedevelopmentoHepatocellularcancer.Cancersevolvedromcontinualchangesinthemicroenvironmentandoalldiseaseshesaidithastoadapttochangesinenvironmentthemost.Epigeneticchangesplayacausalroleincancertheresnoquestionaboutthatanymore.-JaniceDicksonAndrewFeinbergPhotobyJean-MarcCarisse2014 17imultaneousclimatechangeandpopulationgrowthwillincreasepressureongenomicsresearcherstopushcroptechnologiesorwardDuPontPioneerresearcherDoaneChilcoattoldellowscientistsassembledinOttawa.SpeakingattheGenomicsTePowerTePromiseconerenceinOttawaChilcoatsaidagricultureisacingproductivitychallengesresultingromrisingglobaltemperatures.Farmersarealreadyrunningintogreaterproblemsromdroughtanddrierclimatesconditionsthathesaysarealmostsuretocontinue.Teproblemsareonlycompoundedbyprojectionsthattheworldspopulationisexpectedtoincreaseto9.4billionpeopleby2050withmoreothosepeoplejoiningthemiddleclassandlikelyconsumingmoreoodproducts.Cropproductivityperhectarehasalreadydoubledoverthepastfvedecadesthankstoimprovementsinweedandinsectcontrolalongwithimprovedvarietiesheexplained.SAgricultureisfacingproductivitychallengesresultingfromrisingglobaltemperaturesClimateCropsAPPhotoEdAndrieski 18StillChilcoatwarnedthegrowingpopulationnumbersmeanyieldswillneedtoincreasetwo-oldagainby2050tomeetthehigherdemand.Withmostotheworldsqualityagriculturallandalreadyinproductionadvancementsincropdevelopmentandtheemergenceonewvarietiesisessentialithearmingsectorwantstoremaincompetitive.Currentadvancementsincroptechnologiesandvarietiesaresimplyinadequatehesaid.Moreworkneedstobedonetoimprovedroughtresistanceanddiseasepreventionhesaidparticularlygiventhewarmingclimate.Atwo-degreeincreaseintemperatureisahardergrowingconditionorcropsthana20percentdecreaseinrainallhesaid.Meanwhilethewarmertemperaturesduringthewintermonthsmeanewerinsectsarekilledowhichleadstoproblemswithpeststheindustrymaynothavehadtoaceormanyyears.DroughtcandecimateyieldsChilcoatsaidasexperiencedbyarmersintheU.S.mid-westandCaliorniawheredroughthasdevastatedcropsandorcedarmerstoshrinkthesizeotheirlivestockherds.Todaysseedsaresimplynotsuitableorutureconditionshesaid.Withthisinmindplantbreedershaveturnedtogenomicsandplantgeneticstotryandndsolutionswithmuchotheireortsocusedondevelopingdroughtresistancevarieties.AmongtheworkbeingdoneChilcoatexplainedisanexaminationothearchitectureoaplantslea.Abroaderleahesaidwouldhelpplantsretainmorewaterwhichcouldhelpduringdrytimes.ResearchersthougharealsolookingtoimprovepestanddiseasetoleranceincludingworkonwheatrustarmywormandcornrootwormChilcoatsaid.EnBrEfLeschangementsclimatiquesrapidesetlacroissancedelapopulationmondialeexercentdespressionssurleschercheursengnomiquepourquilsmettentaupointdenouvellestechnologiesagricoles.CestcequafrmeDoaneChilcoatchercheurDuPontPioneerquirecommandedeporteruneattentionparticulirelvolutiondesculturesetlmergencedesnouvellesvarits.Ilprconisegalementdetravailleramliorerlarsistancelascheresseetauxmaladies.Plusieursprojetssontencoursnotammentleprojetsurlarchitecturedeseuillesdesplantes.SelonM.Chilcoatenseconcentrantsurltudedescaractristiquesdesplantesdemeilleuresvaritspourronttremisesaupointetaiderontlesecteuragricolerpondreauxexigencesduutur.Todaysseedsaresimplynotsuitableforfutureconditions 19ByfocusingonaplantstraitsliketemperaturetoleranceprecipitationneedsandthenumberofheatunitsneededforaplanttogrowbettervarietieswillhelptheindustrymeettheemergingdemandsheadonChilcoatsaid.-KelseyJohnsonDoaneChilcoatPhotobyJean-MarcCarisse2014PhotobyNelsonChingBloomberg 20hegenomicsworldneedstoworkonitssalespitchiitwantstondbetteruptakeintheextractiveindustrytheconerenceheardWednesday.TeenvironmentalstressescausedbyminingbothinmetalsandoilsandsputatremendouscostoncompaniessaidLesleyWarrenproessoratMcMasterUniversity.Itmakesthesectorertilegroundorgenomicssciencespecicallytheengineeringosomewaste-eatingmicrobesshesaid.OnaveragetheCanadianminingindustryusesabouthalthecountrysrenewablewatersupplyeveryyearinextractionprocessesthatleavebehindvastamountsotailingwastesaidWarrenwhospokeduringthenalroundotalksattheGenomicsTePowerTePromiseconerenceattheOttawaConventionCentre.Miningusesabout12oourrenewablewatersupplyapproximatelythevolumeoLakeOntarioeveryyearshesaid.Terearearound29000abandonedminesinCanadamanyowhichleakintothenearbyenvironmentinaprocessreerredtoasacid-minedrainagesaidWarren.Tebiochemicalpropertiesotheseleaksareusuallyquiteconsistentnomatterwhereyoundthemandarealreadythehometocountlessmicrobesthateatwastematerialshesaid.Teneedorbetterandasterclean-upmakesminingabufetortheexpansionogenomicsshesaid.ExtractivesTTheCanadianPressJeffMcIntosh 21AllwereallyneedtodoisunderstandhowthosemicrobialcommunitiesintheenvironmentarepluggingintothosereactionssaidWarren.Tepotentialextendsbeyondwaterqualitytoclimatechangegiventherecentdiscoveryomicrobesoundintailingpondsthatreducecarbondioxideemissionsromwasteshesaid.Tesendingshoweverarentuseulorregulatorswithoutmorecontextualresearchliketherateatwhichsomeothesemicrobesworkandspecicsiteswheretheycanbeampliedshesaid.InDecember2012WarrenledateamoresearcherstoaSyncrudeoilsandstailingacilitytoinvestigatehowmicrobesareinvolvedinreclamation.OilsandsproducerSyncrudeisrunningapilotprojectwheretailingsthatcantbeledryaremixedwithsandandothermaterialstoresembleawetlandecosystem.Onedangerousbyproductothisexperimenthasbeenhydrogensuldewhichistoxiccorrosiveandexplosive.IitgetstohighlevelsitsalittlebitlikeputtinglipstickonabombsaidWarren.Teresearchersworkconsistedoexaminingthechemicalandmicrobialpropertiesothereclaimedwetlandsatdierentdepths.ByndingmatchesbetweencertainbugsandcertainchemicalsWarrensteamwasabletoshowthatreactionsweretakingplaceinthewastematerial.Teresahugepotentialormicrobestobedoingsomethinginthatmaterialanditsneverbeeninvestigatedbeoreshesaid.Tisisntthersttimemininghasleanedonmicrobesorhelp.Teindustryrststartedusingbacterialleachingaprocesswherebybacteriaormicroorganismsareusedtoseparateadesiredmetalromclumpsooreinthe1940ssaidRickLawrencepresidentoVancouver-basedLawrenceConsulting.enpercentothecopperproducedinChileisproducedbiologicallysaidLawrence.TatamountislargerthantheannualcopperproductionoCanadaChinaandtheU.S.combinedhesaid.Bienquilsoitencoretrspeuexplorlesecteurdelextractionminireestunterrainertilepourlasciencegnomique.SelonLesleyWarrenproesseurelUniversitMcMasterlesperturbationsenvironnementalesquengendrelexploitationminiremtauxousablesbitumineuxsontlapreuvequilautporterattentionlenvironnementmicrobienquiyestassoci.Elleexpliquequelagnomiqueenprenantdelampleurdevrasattarderdavantageltudeetlanalysedesmicrobesquisenourrissentdedchetsminiersandencomprendreetdenexploiterleonctionnement.RickLawrencedelarmedexperts-conseilsLawrenceConsultingafrmequelesecteurminierneseepasbeaucoupauxprocessusbiochimiquesparcequonneconnatpasassezleuronctionnement.Ilsuggreauxchercheursdamliorerlaprsentationdelinormationscientiqueandelarendreplusaccessibleauxtravailleursdusecteurextracti.EnBrEf 22EchoingWarrenscommentsLawrencesaidthebarriertoexpandingthatrelianceonbiochemicalprocessesisimprecisionabouthowitworks.Itsablackboxwehavenoideawhatgoesintoourheapsorourtanksthatwereusingtodevisetechnologyhesaid.Wejusttreatitlikeanotherlayerotheshellacidbugsnutrientswedontknowwhatthepartsdobuttheyworkverywell.Teproblemisalsopackagingresearchinawaytheminingindustrycanunderstandhesaid.TeresnooneromtheminingindustryatthismeetingsaidLawrence.Itsnotbecauseoalackointerest.Itsbecausetheycomeandtheyleavenotknowingwhatitisyouhavetoofer.Itsacommunicationproblemhesaid.DuringapaneldiscussionollowingLawrencesremarksUniversityoCapeBretonpresidentDavidWheelersaidonewaytoimprovethisobstacleistotailortheopportunityineconomicterms.Teresmoneytobemade...whetheritsabandonedminesortheoilsandssaidWheelerwhopointedtoCapeBretonsownproblemswithpollutionromitsnow-shutteredcoalmines.Butintheprocessondingwaystoclean-upancientwasteLawrencecautionedagainstblamingtheminingindustryornotmeetingenvironmentalstandardsthatdidntexistwhenthemineswereoperational.Itseemstheindustryisbeingheldtoenvironmentalaccountorthingsthathappened100yearsagohesaid.WhencomparedtotheuseogenomicsintheorestryandagriculturesectorstheideasthatcouldbeuseultotheextractiveindustryaresimplynotyetmatureenoughsaidJavierGracia-GarzaadirectorgeneralatNaturalResourcesCanada.Butthereisaroleorgovernmentincreatingincentivesorpromisinguseshesaid.AlototheseemergingtechnologiesdoneedapolicypushatthesametimeasthescienticadvancesandtechnicalpushesbeingdevelopedsaidGracia-Garza.LesleyWarrenPhotobyJean-MarcCarisse2014 23Warrentheoilsandsresearchersaidtheproblemisoenthatminersthinktoomuchlikeengineersandnotenoughlikebiochemists.Butpeopleingenomicsneedtomovepasttheirownexcitementaboutthevastpotentialotheireldaswellshesaid.IyougoinandsayImgoingtogiveyoutheullmetabolicpathwaystheyregoingtosayWhatdoIdowiththatWarrensaidinreerencetochemicalreactionswithinacell.Ithinkyouhavetoparksomeothesesophisticatedideas.DowntheroadtheymightbeuseulbutigenomicsexpertssimplysaythataspecicspeciesmighthelpmakethemmoreefcientthatsallweneedtotellthemsaidWarren.LikeGracia-Garzasheemphasizedaminingcompanysnancialconsiderationsinexploringgenomicsresearch.Teindustryhasbeenburnedmanytimesbybiologically-basedapproachesitscostthemalotomoneysaidWarren.WecandoallothesethingsbutIthinkyouhavetoalwaysgroundtheseandsaywhatwouldbethemosteectivewayorustohelpindustrynowshesaid.Wedontneedthebiggesttoolsalototimesitcanbeverysimple.-JamesMunsonJavierGracia-GarzaPhotobyJean-MarcCarisse2014 24Micro-OrganismsMininganadaisortunatetohaveaplethoraonaturalresources.InNovaScotiaalonetheminingindustryisturningsomeothoseresourcesinto5500jobscontributing420milliontotheannualeconomyandocourseprovidingtherawmaterialsorproductsthatareusedeveryday.Butallothatdoesntcomeeasily.Globallytheminingsectoracesenvironmentalchallengesrisingproductioncostsandfuctuatingpricesthatwarrantsubstantialinterestindiscoveringnewsolutionstoextracttheseresourcesinthemostecientandsustainableway.Deloittes2014rackingtherendsreportonminingsaysMinersshouldinnovatebyadoptingtechnologiestoenableminedesignandplanningenergysupplyaswellasadoptionoemergingtechnologies.OneothoseemergingareasotechnologyisgenomicsthecombinationogeneticsbiologyandcomputersciencethatstudiestheDNAinalivingorganism.Tismayseemanunusualocusorasectorlikeminingbuthiddenwithintherocksanddirtarecountlesscommunitiesomicroscopicorganismsknownasmicrobessuchasbacteriathatcouldplayagiganticroleinthesector.Tesemicrobialconsortiaaretremendouslydiverseandresourceul.Teyhavebeenaroundorbillionsoyearsandcanthriveinenvironmentsthataretoxictohumans.Aroundtheworldtheminingindustryhasbeenusingmicrobestosaelyremediateorquitesometime.Muchotheworldscopperisactuallyextractedbymicrobesbioleaching.Sothesebiologicalapproachesaretechnicallynotnew.Whathaschangedisourabilitytostudythesecomplexlittlebeingsthroughgenomics-basedtechnologies.CSTEvEARMSTRONGPresidentCEOGenomeAtlanticCARLWEATHERELLExecutieDirectorCEOCanadianMiningInnoationCouncilJEANvAvREKExecutieDirectorCanadianInstituteoMiningMetallurgyandPetroleumThiscommentarywasfrstpublishedintheHaliaxChronicle-HeraldonNo.122014DanslesprovincesdelAtlantiquelagnomiqueestporteusedegrandespromessesparticulirementdanslesecteurdesressourcesnaturelles.Secteurdactivitcldelconomiergionaleilaitacedegrandsdsenvironnementauxsurtoutencequiconcerneledrainageminier.Lagnomiquepeutrenseignerlesscientiquessurlavieetlemodedeonctionnementdesconsortiumsmicrobienscapablesdetransormerlesdchetsminiers.Leconceptnestpasnouveaumaislesscientiquescomptentsurlagnomiquepourmieuxanalysercesmicrobesetexplorerlespossibilitsdeleurutilisationdanslessecteursdesminesetdesressourcesnaturelles.Lesauteursdelarticlesontoptimistescarlarechercheestsurlepointdednirdesmoyensecacesquipermettrontdutiliserlesmicrobesdansunlargeventaildedomaineslisauxminesdontceuxdelabiosurveillanceetdelabiorestaurationdemmequelmergencedapprochesdedrainageplusperectionnes.EnBrEf 25Withgenomicswevegainedaremarkableabilitytounderstandthesemicrobialcommunities.Wearendingspeciesthathaveneverbeenidentiedbeoreandlearninghowtheyarebehavingintheseuniqueenvironments.Temoreweunderstandwhatmakesthemtickthemoreopportunitiestherearetoleveragetheirapplicationinminingandotherresourcesectors.Wearenowonthecuspoemployingmicrobesmuchmoreefcientlytohelpusinawiderangeominingareasincludingasterandmoreaccuratebio-monitoringandbioremediationlessresource-intensiveextractionextractionromlow-gradeoresaswellasrenedapproachestoacidminedrainage.TeseareexcitingopportunitiesorthoseinNovaScotiasminingindustry.Teyaredirectlyalignedwiththesentimentsoundinthemuch-reerencedOneNovaScotiareportIwewanttoseechangeweneedtodothingsdierently.Acrossthecountryorganizationsareworkingtohelptheminingsectorseizethegenomics-basedresource-andcost-savingopportunities.GenomeAtlanticisintroducinglocalminingcompaniestoworld-classgenomicsexperts.TeCanadaMiningInnovationCouncilCMICandtheCanadianInstituteoMiningMetallurgyandPetroleumCIMareworkingwithmanyregionalGenomeCentresandotherresearchdevelopmentandinnovationcentrestoestablishnationalpilotprojectsthatcandemonstratetheviabilityotheseapproachesorthesectorandidentiyotherpotentialapplicationsogenomicsthatcouldprovidegame-changingsolutionstosomeotheindustrysgreatestchallenges.Tisisatimewhenboththeprovinceanditsminingsectorarebeingchallengedtodigdeeptocomeupwithinnovativesolutions.WeareoeringtheexpertisetechnologiesandprogramstomakeithappensowecanallenjoythebenetsoaprotableandsustainableminingindustryinNovaScotia.PhotobyHansLindqvist 26NaturalResourcesromGrosMornesmajestytothewildwestcoastoVancouverIslandthereisalinkthatconnectsthetreesonthemountainstotheshandmarinelieintheoceantothecellsinourbodiesandbeyond.TelinkistheDNAthecommonevolutionarythreadbetweeneverylivingorganism.TisexcitingeldoscienceisnowbeginningtooerrealsolutionsinsupportoCanadaskeysectorsincludingagri-oodssheriesandaquacultureenergyandminingorestryandhealth.Genomicsisalsoanintegralpartothewestcoastsbioeconomythattodaycontributesanestimated2billiontoBritishColumbiasGDPand14000BC-basedjobs.ByattractingtherightinvestmentsthebioeconomyinBCcouldreachover12billioninGDPandsupport56000jobsby2030.Canadasgenomicsrevolutionbeganin2000withtheoundingoGenomeCanadaandsixregionalGenomeCentresacrossCanada.Tesharedobjectivewastocapitalizeonthepromiseogenomics.BackthentheHumanGenomeProjectwasthreeyearsromcompletionandscientistshadonlyvaguenotionsothepowerogenomics.odaythatpromisehasbecomeareality.GenomicsplaysakeyroleinaddressingsomeothemajorchallengesacingCanadasnaturalresourcesincludingadaptingtoclimatechangeeedinganexpandingpopulationndingalternativeuelsandmitigatingtheenvironmentalconsequencesoeconomicexpansion.CLEANINGUPMINESIntheminingindustrysaetyprecautionsaroundminedrainageandwastewaterareoparticularconcernnoonewantstoxiccompoundsromminingoperationsfowingintosh-bearingstreamsandourwaterways.oensureoptimalsaetylevelschemicalsaretypicallyusedtotreatmetalleachingandacidrockdrainage.Tesetreatmentswhileeectivearealsohighlyexpensiveandproducetheirownwastebyproductswhichmustthenbecareullycontainedoryearstocome.Manyminingcompaniesareinvestingmoreintobioremediationtechniquestodecontaminateminingwastewater.GiventherecenttailingpondsbreachatMt.PolleyMinethereisagrowingdemandormoreecientandeectivebioremediationtechniques.GenomeBChasundedUniversityoBritishColumbiaresearcherDr.SusanBaldwintohelpmovegenomicssciencetowardsapplicationmakingbioremediationamoreeconomicalandaccessibleoptionbyapplyinggenomicstoharnessthedetoxiyingbiologicalprocesses.Dr.Baldwiniscurrentlyworkingtogatherdataonmicroorganismsthatliveandthriveincontaminatedminewaterandtondwaystoapplythisknowledgetohelpimproveminingsaetyandquality.ROOTSOFCHANGETeorestsectoristremendouslyimportanttoCanadabothasaneconomicdriverandaculturalicon.AsCanadaslargestrenewablenaturalresourcetheorestsectorgeneratedabout54billioninrevenuesin2010andcontributedabout24billiontoGDP.Forestryalsoprovidesroughly234000directjobsandinsome200ruralCanadiancommunitiesthissectormakesupatleast50otheeconomy.HealthyCanadianorestsalsoplayacriticalroleinprovidingahostoecosystemservicesincludingthoserelatedtoregulatingglobalcarbonemissions.Canadaenjoysworld-classsustainableorestmanagementregulationsandcerticationsinalljurisdictions.GenomicsisplayingakeyroleinaddressingorestchallengesincludingclimatechangebydeterminingwhattreestobreedFALANWINTERPresidentandCEOGenomeBritishColumbia 27howtomatchspecicbreedstothepreerredgrowingenvironsandhowtobattleinvasivepestsandpathogenssuchashowtodealwithinestationslikeMountainPineBeetle.GenomicsisapowerultoolinthebattletokeepCanadianorestshealthyandprosperous.UNCORKINGTHESECRETSOFTHECHARDONNAYGENOMETequalityowineproducedinCanadahassteadilyincreasedsincetheveryearlydaysoruitwinesthatweremadeprimarilywithermentedapples.NowtheCanadiangrapeandwineindustrygenerates6.8billiontotheeconomy.ChardonnayisthesecondmostabundantwhitewinegrapevarietyinCanadaandtheworldbehindpinotgris.TiseconomicsignicancepairedwiththefexiblearomaandfavouroChardonnaygrapeshasgivenrisetoanumberograpevineselectionandbreedingprogramswiththegoalodevelopingnewgrapecharacteristics.HoweververylittleisknownabouttheChardonnaygenome.Dr.HennievanVuurenwiththeWineResearchCentreattheUniversityoBritishColumbiahasteamedupwithsomeoBCswinemakerstoidentiythegeneticmarkersodesirabletraitslikeberrysizevineyieldsandtolerancestoheathumidityanddroughtorChardonnaygrapes.GettingaullpictureotheChardonnaygenomewillenablegrowersandwinemakerstomakeinormedchoicesaboutwhichclonestoplantleadingtobettergrapesandhigherqualitywine.SOLvINGPUZZLESONEGENOMEATATIMETejourneytowardsndingsolutionsisnoteasytohelpbridgethegapbetweenresearchersinthelaboratoryandend-usersintheoresteldclinicorelsewhererobustbusinessdevelopmentprogramsworkinthebackgroundtospantheresearchcontinuumromdiscoverytotranslationandcommercialization.Troughdialogueandengagementwithend-userstakeholdersGenomeBCrecognizesaneedtobalancetheresearchpushandend-userpullogenomicstechnologiesinordertobetterostertheuptakeandimpactothesetechnologies.Scienticresearchinvestmentsareparamounttotheidenticationanddevelopmentonewinnovationsandnowthesearecomingtoruition.EnColombie-BritanniquelagnomiqueaitpartieintgrantedelabioconomieprovincialeetcontribueauPIBdelaprovince.SelonAlanWinterprsident-directeurgnraldeGnomeColombie-Britanniquesidesinvestissementsjudicieuxsontaitslabioconomiepourraitreprsenter12milliardsdedollarsdanslePIBprovincialetsoutenir56000emploisen2030.Dansledomainetrsimportantdudrainageminierparexemplelagnomiquepermettradorienterlarechercheversdestechniquesdebiorestaurationplusrespectueusesdelenvironnement.Enoresterielagnomiqueamlioreralaluttecontrelesinestations.LagnomiqueestgalementindispensableladterminationdesmarqueursgntiquesgrceauxquelsdemeilleuresespcesdevignesdeChardonnayserontmisesaupoint.GnomeC.-B.reconnattouteoislimportancedecrerunpontentreladcouvertedestechnologiesissuesdelarechercheengnomiqueetleuradoptionparlesutilisateursnaux.EnBrEf 28HumanHealthheeldomedicineisconstantlyevolving.Allovertheworldresearchersarealwayshardatworkseekingnewmedicationsandstrategiestotreatandcurepatients.Tediscoveryothedouble-helixstructureoDNAin1953andyyearslatertheabilitytosequenceacompletehumangenomechangedoreverthehistoryoresearchinhumanhealth.Sincethentheenergyandmoneypreviouslyinvestedinbasicgenomicresearchhavebeendirectedtowardappliedmedicalresearchleadingtoimprovementsindiagnosestreatmentandprevention.QUEBECEXPERTISEATWORKFORALLCANADIANSManycountriesincludingCanadaandtheUnitedStatesaremakingtheshitowardpersonalizedmedicine.WithathrivinghumanhealthresearchsectortheprovinceoQuebecisnoexceptiontothistrend.AsevidenceeightQuebecresearchprojectswererecentlyselectedunderthenationalcompetitionorganizedbyGenomeCanadaandtheCanadianInstitutesoHealthResearch.Teselarge-scaleprojectsocusprimarilyondevelopingpracticalhealthcareapplicationsthathavethepotentialtoreachthemarketplacewithinouryears.OneotheseprojectsspearheadedbyDr.CossetteattheCentrehospitalieruniversitairedeMontrealisexpectedtoimprovethelivesopatientslivingwithepilepsy.Itinvolvesthedevelopmentoapharmacogenomictoolthatcanmoreaccuratelypinpointthevariousormsoepilepsyandmorespecicallyitsdrug-resistantvariants.Tankstothisdecision-makingsupporttooldoctorscanarriveatadiagnosisandidentiytreatmentoptionsinamoretimelymannerhelpingtopreventnegativeconsequencesothediseasesuchascognitivedeclineinyoungpatients.Teseprojectswillnotonlygenerateover100millionininvestmentsingenomicstheywillalsoleadtothedevelopmentodiagnostictoolsandtreatmentsinawidevarietyoareassuchascancerneuroscienceheartdiseaseinfammatorydiseasespediatricsandrarediseases.ANEWERAFORCHILDRENPediatricsandrarediseasesaretwoparticularlyactivesectorsinQuebecandCanada.TecriticalmassotechnologyandexpertiseacquiredinrecentyearshaveledtoapartnershipbetweenGnomeQubecandtheCHUSainte-JustineresultinginthelaunchoCanadasrstintegratedclinicalgenomiccentreinpediatrics.Tisinnovativecentrewillpavethewaytowardnewsolutionsorchildrensueringromgeneticdiseases.Itwillalsotransormthequalityocarethroughbetterpreventioninearlychildhood.Tisinitiativeisatthecuttingedgeoprogressbeingmadeintheworldtodaygivinghopetochildrenandtheiramiliesaectedbyillness.AccordingtoDr.JacquesL.MichaudadoctorandgeneticistattheSainte-JustineUHCanddirectorothecentreOver80percentogeneticdiseasesarediagnosedinchildhoodoradolescence.Withnewgenomictechnologieswecansequenceallthegenesoachildsgenomedevelopageneticprolemorequicklyestablishadiagnosisanddeliverthetreatmentioneisavailableoratthetimeitbecomesavailableintheuture.TGenomicsisdrivingmajoradvancesinhumanhealthMARCLEPAGEPresidentandCEOGnomeQubec 29Genomictechnologyhasnowreachedthepointwhereintheverynearutureitwillbeusedtotreatpatientslivingwithgeneticdiseasespreventandscreenorillnessesandimprovepublichealth.PROMISINGPARTNERSHIPSFORCANADAButQuebecisnotworkingalone.Othermajorpan-CanadianpartnershipsintheeldarecurrentlyunderwayorinstanceDr.MichaudsinvolvementintheOntario-basedCAREorRARE.RAREisacollaborativeteamocliniciansbioinormaticiansscientistsandresearcherswhoarebuildingupontheinrastructureanddiscoveriesotheFORGECanadaFindingoRareDiseaseGenesprojectwhichtodatehassolvedover77disordersthroughsequencingtechnology.TegoaloCAREorRAREistoimproveclinicalcareorpatientsandamiliesafectedbyrarediseases.TistypeopartnershipisbringingtogethertheexpertiseandtalentsoourCanadianresearchershelpingCanadarankamongtheworldsbestandurtheringitsgloballeadershipinpediatricclinicalgenomicsandpersonalizedmedicine.amdecineapourparticularitdtreenperptuellevolution.Partoutdanslemondedeschercheurstravaillentdanslebutdetrouverdenouveauxmdicamentsetdenouvellesstratgiespourtraiteretgurirlespatients.LadcouvertedelastructureendoublehlicedelADNen1953etlapossibilitdeairelesquenagecompletdugnomehumaincinquanteansplustardontmarqudemanireindlbilelhistoiredelarechercheensanthumaine.Letempsetlesinvestissementsconsacrslarechercheondamentaleengnomiquesesonttranspossverslarecherchemdicaleappliquepermettantainsidamliorerlesdiagnosticslestraitementsetlaprvention.UNEEXPERTISEQUBCOISEQUIPROFITELENSEMBLEDELASOCITCANADIENNEDenombreuxpayscommeleCanadaetlestats-Unisontainsiamorcletournantverslamdecinepersonnalise.EtlaprovinceduQubecnapaschappaumouvement.Cettederniresedmarquegrceaudynamismedusecteurdelarechercheensanthumaine.LeshuitprojetsderecherchequbcoisnancsdanslecadreduconcoursnationalinitiparGnomeCanadaetlesInstitutsderechercheensantduCanadaillustrentbiencetteralit.Cesprojetsgrandechelleaxsprioritairementsurlesapplicationsensoinsdesantontenefetlacapacitdepntrerlemarchdansunhorizondequatreans.titredexemplementionnonsleprojetduDrCossetteduCHUdeMontralquiauraunimpactsurlapratiquemdicaledansledomainedelpilepsieceprojetvisedvelopperunoutilpharmacognomiquequiSantHumaineLLagnomiqueaucurdesgrandesavancesensanthumaineMARCLEPAGEPresidentandCEOGnomeQubec 30pourraitchangerlaviedespatientsenpermettantdediagnostiquerplusprcismentlesdirentesormesdpilepsienotammentlapharmacorsistante.Cetoutildaideladcisionpermettradacclrerladmarchediagnostiqueetlechoixdunethrapieetcontribueraprvenirledclincognitichezlesenants.CesprojetsquignrerontauQubecplusde100millionsdedollarsdinvestissementdanslesecteurdelagnomiquepermettrontpluslargementledveloppementdediagnosticsetdetraitementsdansdesdomainesaussivarisquelescancerslesneuroscienceslesmaladiescardiovasculaireslesmaladiesinfammatoireslapdiatrieetlesmaladiesrares.UNENOUvELLEREPOURLESENFANTSCesdeuxderniersdomainessontparticulirementdynamiquesauQubecetauCanada.EneetgrcelamassecritiquedestechnologiesetdesexpertisesacquisescesderniresannesuneententeaprisormeentreGnomeQubecetleCHUSainte-JustinedonnantnaissanceaupremiercentredegnomiquecliniquepdiatriqueintgrauCanada.Cecentrehautementinnovantpermettraledveloppementdenouvellessolutionsaceauxdsdiagnostiqueschezlenantquisouredunemaladiegntique.Cetteinitiativetransormeralaqualitdessoinsoertsauxjeunespatientsenvuedunemeilleureprventiondslenance.Ilsagitduneinitiativelavant-gardedecequiseaitactuellementdanslemondeetquiinsueunventdespoirauxenantsmaladesetleursamilles.SelonleDrJacquesL.MichaudmdecingnticienauCHUSainte-JustineetdirecteurduCentreplusde80desmaladiesgntiquessedclarentdurantlenanceouladolescence.Lesnouvellestechnologiesgnomiquesnouspermettronsdesquencertouslesgnesdugnomeetdobtenirplusrapidementunportraitgntiquedelenantdesavoirdequellemaladieilsoureetdoriruntraitementsilestdisponibleoulorsquilledeviendraa-t-ilconclu.Latechnologiegnomiqueaatteintuntelniveaudepotentielquonpourradansunavenirtrsrapprochlutiliserpourtraiterlespatientsatteintsdemaladiesgntiquesmaisgalementdansuneperspectivedeprventiondedpistagevoiredesantpublique.DESPARTENARIATSPORTEURSPOURLECANADAMaisleQubecnetravaillepasseul.DimportantescollaborationspancanadiennesdanscesecteursedveloppentnotammentaveclaparticipationduDrMichauddanslecadreduprojetontarienCAREorRARE.CAREorRAREregroupeunequipedecliniciensdinormaticiensetdechercheursdveloppantlinrastructureetlesdcouvertesduprojetFORGECanadaDcouvertedegnesdemaladiesraresquicejourarsoluplusde77troublesenutilisantlesnouvellestechnologiesdesquenage.LobjectidessoinsdeCAREorRAREestdamliorerlessoinscliniquespourlespatientsetlesamillestouchesparlesmaladiesrares.CetypedecollaborationsquimetenvaleurlesexpertisesetlestalentsdenoschercheurscanadienspermetaupaysdesepositionnerparmilesmeilleursdanslemondecepositionnementestessentielpourdvelopperleleadershipduCanadalchellemondialeenmatiredegnomiquecliniquepdiatriqueetdesoinsdesantpersonnaliss.HumanHealth 31PhotosbyJean-MarcCarisse2014TerryHazenGerardoJimenez-SanchezpowerofgenomicsBonnieSchmidtL.IanMacDonaldfarrightmoderatesapanelPosterprizewinnersLauraBradenDianaGranadosandBeatriceAmyotteAposterpresenterexplainsherresearch 32congres2015.cacongress2015.caGenomeCanadawillbeatCongress2015Staytunedandvisitcongress2015.caformoredetailsonGenomeCanadasprogrammingonpublicpolicyissuesattheinterfaceofgenomicsandsocietyGnomeCanadaseraauCongrs20155bonnesraisonsdassisterauCongrs2015lUniversitdOttawaAPPRENEZ-ENdavantagesurlesavancesdansvotredomaineBRILLEZenprsentantvostravauxderechercheauCongrs2015SAISISSEZsocialesduCongrs2015DVELOPPEZvotrecarrireenassistantauxsancesdelaFoireauxcarriresEXPLOREZ5greatreasonstoattendCongress2015attheUniversityofOttawaLEARNSHINENETWORKatoneofCongress2015smanysocialeventsGROWyourcareerwithsessionsatCareerCornerEXPLOREthelinksbetweenresearchandpolicyinCanadascapitalcitySuivezlesactualitsetvisitezcongres2015.capourconnatrelaprogrammaondeGnomeCanadasurlesenjeuxdespoliquespubliquesaucarrefourdelagnomiqueetdelasocit DISCOVERERSPIONEERSPOSTERSESSIONSGALATABLESConferenceSponsors 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