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NanoString nCounter Vantage 3D platform-based complementary diagnostic tests for precision medicine in pediatric cancers

Status: 
Active
Competition: 
Genomic Applications Partnership Program
Sector: 
Health
Genome Centre(s):
Ontario Genomics
Project Leader(s):
Cynthia Hawkins (The Hospital for Sick Children)
Receptor Leader(s):
Sean Ferree (NanoString Technologies)
GE3LS: 
No
Fiscal Year Project Launched: 
2019-2020
Project Description: 

DNA-based next generation sequencing provides important information about DNA alterations however, most oncology drugs are designed against defined molecular targets at the protein level. There is a pressing need for novel diagnostics that interrogate all levels of cellular information, protein, RNA and DNA, in order to best guide therapeutic choices. This project aims to amalgamate proteomic data with genomic and transcriptomic information to develop laboratory developed (LDT)-complementary diagnostics for the most common pediatric cancers. Furthermore, the partnership between NanoString Technologies and the SickKids Department of Paediatric Laboratory Medicine will leverage their combined technological, clinical and business expertise.