b'CENTRES SECTOR LEADERS ORGANIZATIONS TITLE TOTALGENOME CANADA FUNDING CONTRIBUTIONLcuyer, EricThe RNA Zipcode Discovery Genome Qubec All Blanchette, MathieuInstitut de recherchesPipeline: Emerging Tools for$250,000 $250,000Waldispuhl, Jrome cliniques de Montral Targeting Therapeutic Mol-ecules at Subcellular ResolutionGenome Qubec All Juncker, David McGill University Digital Omics of Single$2,001,438 $667,157ExosomesA Cell Microfactory Platform Genome QubecTyers, Michaelfor in vivo Biosynthesis and Ontario Genomics All Wright, Gerard Universit de Montral Delivery of Genetically Encoded$249,358 $249,358Natural Products and Synthetic AntibodiesBoone, CharlesAbSyn Technology for Identi-Ontario Genomics All Moffat, Jason University of Toronto fication of Synergistic Cancer$249,389 $249,389TherapeuticsDowling, JamesThe Hospital for SickRNA-seq in Patient-Derived ex-Ontario Genomics All Brudno, Michael Children vivo Models: Genetic Diagnostics$250,000 $250,000beyond Whole ExomesOntario Genomics All Emili, Andrew University of Toronto Massively Parallel Single Molecule$250,000 $250,000Protein Sequencing in SituOntario Genomics All Figeys, DanielUniversity of Ottawa RapidAIM: a High-Throughput$250,000 $250,000Stinzi, Alain Assay of Individual MicrobiomeDevelopment of Advanced Ontario Genomics All Finan, Turlough McMaster University Genetic Toolbox for$250,000 $250,000Sinorhizobium Meliloti to Enable Genome Scale EngineeringOntario Genomics All Krell, PeterUniversity of Guelph Cell Biosensors for Rapid$233,901 $233,901Doucet, Daniel Screening of Insect AttractantsScherer, StephenThe Hospital for SickEconomical High Throughput Ontario Genomics All Lok, Si Children de novo Whole Genome As- $241,467 $241,467semblyDevelopment of SIMPL, a Novel Ontario Genomics All Stagljar, Igor University of Toronto Protein-Protein Interaction$250,000 $250,000Assay based on Split Intein for Biomedical ResearchTabard-Cossa,Solid-State Nanopore-based Ontario Genomics All Vincent University of Ottawa Quantification of Low- $250,000 $250,000Abundance BiomarkersTaylor, MichaelThe Hospital for SickFunctional Genomics in Human Ontario Genomics All Khokha, Rama Children Cells for Drivers of Lethal$250,000 $250,000Metastatic Human CancersDevelopment of a Digital Microfluidic Platform to Identify Ontario Genomics All Wheeler, AaronUniversity of Toronto and Target Single Cells from a$250,000 $250,000Kolomietz, Elena Heterogeneous Cell Population for Lyses in an Ultra-Low VolumeSANGRE (Systematic AnalysisOntario Genomics All Wilson, MichaelUniversity of Toronto of Blood Gene Regulation$249,934 $249,934Shlien, Adam by Sequencing)Bringing RNAseq to Clinical DiagnosticsOntario Genomics All Sidhu, Sachdev University of Toronto Synthetic Inhibitors of Ubiqui- $3,009,018 $1,000,000tin-Binding Cancer TargetsThe Mammalian Membrane Ontario Genomics All Stagljar, Igor University of Toronto Two-Hybrid (MaMTH) Assay - an$3,034,211 $1,000,000Advanced Proteomics Technol-ogy for Biomedical ResearchRapidAIM: A technology to Ontario Genomics All Figeys, DanielUniversity of Ottawa rapidly assess the effects of$2,888,563 $757,358Stinzi, Alain compounds on individual microbiomesBoone, CharlesAbSyn Technology for Identi-Ontario Genomics All Moffat, Jason University of Toronto fication of Synergistic Cancer$2,719,453 $896,331TherapeuticsShlien, AdamBeyond the Genome: Transcrip-Ontario Genomics All Dowling, James Hospital for Sick Children tome Based Diagnostics for$2,999,944 $999,419Rare Diseases and CancerGenome Canada Annual Report 2018-19 37'