b'Large-scale science Success stories Precision Health: Bringing a National Strategy to Life Precision health has the potential to transform the healthcare experience in Canada. Genome Canada is committed to maximizing the benefits of precision health and is laying the foundation for the implementation of precision health in clinics across Canada through its national strategy. Improving DiagnosesMaking Pre-natal for Rare DiseasesScreening Safe There are more than 7,000 rare genetic diseasesEvery year in Canada, about 10,000 pregnant women in Canada, while a third of them remain unsolved.undergo amniocentesis to screen for genetic abnor-Canadian researchers have developed newmalities. Approximately 70 healthy fetuses are lost expertise in understanding the underlyingdue to complications. Recently, researchers discov-biology of rare childhood disorders throughered that fetal DNA present in the mothers blood exome sequencing, a method of testing can test for genetic abnormalities through a simple all genes at once. The research team, led by blood test. Dr. Franois Rousseau of the Universit Dr. Kym Boycott of the Childrens Hospital ofLaval and Dr. Sylvie Langlois of the University of Eastern Ontario, has already solved hundreds ofBritish Columbia spearheaded the Personalized disorders. This type of genomic sequencing willGenomics for Prenatal Aneuploidy Screening Using speed up diagnostic processes and improve theMaternal Blood (PEGASUS) project to develop the overall care and wellbeing of young patients.safest, most accurate genetic testing for fetuses.Simplified Screening for Breast Cancer Breast cancer is the most common cancer and secondleading cause of cancer death in Canadian women. Yet many women at high risk for the disease are not properly screened. Dr. Jacques Simard of the Universit Laval and his research team have developed a simple saliva test to gauge a womans risk of developing breast cancer, now the most accurate risk-prediction model to date. By combining the genetic profile obtained through the saliva sample with a family history, hormonal factors and lifestyle habits, the researchers can estimate each womans overall risk for breast cancer.4 Genome Canada Annual Report 2018-19'